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KMID : 0644319990050010033
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Journal of Korean Oriental Oncology
1999 Volume.5 No. 1 p.33 ~ p.46
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Study on Antitumor Activity of Samiyeongeontanggamibang(SYTG)
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裵文庸/Bae, Moon-Yong
康仁哲/金聖勳/Kang, In-Cheol/Kim, Sung-Hoon
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Abstract
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To svaluate the antitumor and antimetastatic effects of Samiyeongeontanggamibang(SYTG), We have examined whether SYTG can inhibit the growth of several tumor cell lines, tumor cell adhesion, experimental tumor metastasis and increase survival rate of tumor-bearing mice by inhibition of DNA topoisomrase activity.
The results were obtained as follows:
1. SYTG extracts revealed an efficient cytotoxicity against A549, SK-OV-3, B16-F10, and SK-MEL-2 cell lines.
2. SYTG extracts inhibited DNA topo-isomerase I from calf thymus.
3. The T/C% in S-180 bearing ICR mice treated with SYTG was 115.8%
4. SYTG extracts significantly inhibited adhesion of A549 cell to complex extracellular matrix.
5. In pulmonary colonization assay, SYTG suppressed lung metastases in tumor cell-injected mice.
6. In CAM assay, SYTG extracts inhibited angiogenesis at 15ug/egg concentration as compared with control.
These results suggested that SYTG extracts might be a potent inhibitor of cancer.
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